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IMMUNOLOGICALLY REACTIVE POLYPEPTIDE, POLYNUCLEOTIDE, METHOD AND KIT FOR DETECTION OF THE PRESENCE OF T. CRUZI ANTIBODIES.
IMMUNOLOGICALLY REACTIVE POLYPEPTIDE, POLYNUCLEOTIDE, METHOD AND KIT FOR DETECTION OF THE PRESENCE OF T. CRUZI ANTIBODIES.
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机译:免疫反应性多肽,多核苷酸,方法和试剂盒,用于检测克鲁维酵母的存在。
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摘要
Polypeptides are disclosed that are useful for diagnosing American trypanosomiasis, or Chagas disease, a disease caused by the infectious agent Trypanosoma cruzi. The polypeptides have a sequence that corresponds to the amino acid sequence of at least one of the C-terminal and N-terminal nonrepetitive regions of TCR27 protein. The polypeptide additionally may comprise an amino acid sequence of one or more repeats from the central region of TCR27 protein. In a preferred embodiment, the polypeptide corresponds to the N-terminal nonrepetitive region of TCR27 protein and at least one repeat from the central region of TCR27 protein, and does not correspond to the C-terminal nonrepetitive region. The polypeptides may further comprise a linker sequence at either the N-terminus or the C-terminus to facilitate attachment or conjugation to a carrier molecule in a liquid or solid support system for use in a sensitive assay for detecting T. cruzi infection.
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