Sequences of ribonucleotideos chemically modified as modulators of the activity of receptors purinu00c9rgicos P2Y2 and aptu00c2mero B7

摘要

Sequu00cancias of ribonucleotu00cddeos chemically modified as modulators of the activity of receptors purinu00c9rgicos P2Y2 and aptu00c2mero B7.The present invention relates to a family of 21 sequences of ribonucleotu00eddeos chemically modified by replacement of the group 2 '- Oh of the pyrimidine nucleotides by an atom of fluorine (F - DCTP: 2' and 2 'F - dcutp with high binding affinity to the P2Y2 purinergic receptors, which is a Students in any process involving the signalling purinu00e9rgica via the receiver P2Y2, including,But not limited to, its use as a reagent in pharmacological tests (in vivo and in vitro, citu00f3mica, in diagnostic tests and as an antagonist in therapeutic applications such as, for example, cystic fibrosis, lung injury and emphysema in smokers and cancer, cardio and neuroproteu00e7u00e3o and Neurodegenerau00e7u00e3o as, for example, in glucose reactive caused by neuroinflamau00e7u00e3o.Particularly, the present invention describes the aptu00e2mero B7, presenting a significant affinity and specificity of binding to the P2Y2 purinergic receptors, showing a biological activity inhibitory on the same.