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Ox40 Antibody; Nucleic Acid encodes it; host Cell; production method; and its use to treat cancer or Autoimmune Disease.
Ox40 Antibody; Nucleic Acid encodes it; host Cell; production method; and its use to treat cancer or Autoimmune Disease.
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机译:Ox40抗体;核酸编码它;宿主细胞;生产方法;及其用于治疗癌症或自身免疫性疾病。
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摘要
Human antibodies, preferably recombinant human antibodies, both humanized and chimeric, which specifically bind to human OX40 are disclosed. Preferred antibodies have high affinity for OX40 receptor and activate the receptor in vitro and in vivo. The antibody can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, are useful for modulating receptor activity, e.g., in a human subject suffering from a disorder in which OX40 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies are provided, and methods of synthesizing the recombinant human antibodies, are also provided.
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