2. A Bichemical complex molecule consisting of at least one assembly connecting DL4 and ANG 2 and at least one binding part; a nucleic acid molecule encoding the Bichemical complex molecule; a Thermococcus containing nucleic acid molecule; and Pharmacists Including Molecules

摘要

Bispecific binding molecules binding to both DII4 and Ang2, preferably in the form of immunoglobulin single variable domains like VHHs and domain antibodies, pharmaceutical compositions containing the same and their use in the treatment of diseases that are associated with DII4- and/or Ang2-mediated effects on angiogenesis are disclosed. Further, nucleic acids encoding bispecific binding molecules, host cells and methods for preparing same are also described.