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Composed of a separated polypeptide with inhibitory activities of NAV1.3 and NAV1.7; includes the synthesis of the above components; used in the treatment of pain.
Composed of a separated polypeptide with inhibitory activities of NAV1.3 and NAV1.7; includes the synthesis of the above components; used in the treatment of pain.
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机译:由具有NAV1.3和NAV1.7抑制活性的分离的多肽组成;包括上述成分的合成;用于治疗疼痛。
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摘要
Disclosed is a composition of matter comprising an isolated polypeptide, which is a peripherally-restricted Nav1.7 inhibitor. In some disclosed embodiments, the isolated polypeptide is an inhibitor of Nav1.7 and/or Nav1.3. Other embodiments are conjugated embodiments of the inventive composition of matter and pharmaceutical compositions containing the inventive composition of matter. Isolated nucleic acids encoding some embodiments of inventive polypeptides and expression vectors, and recombinant host cells containing them are disclosed. A method of treating or preventing pain is also disclosed.
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