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Selective Metabolic approach to improve oral bioavailability of phenylephrine and other bioactive phenolic
Selective Metabolic approach to improve oral bioavailability of phenylephrine and other bioactive phenolic
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机译:选择性代谢方法可改善去氧肾上腺素和其他生物活性酚的口服生物利用度
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摘要
Presystemic metabolism in intestine of bioactives such as phenylephrine is avoided by administering a subject (human or animal) the bioactive (e.g., phenylephrine) in combination with one or more inhibitors of sulfation (e.g., sulfotransferase enzymes aka SULTs). This can also be enhanced be co-administering inhibitors of monoamine oxidases aka, MAOs, and uridine diphosphate glucoronysl transferases, aka UGTs. Preferably the inhibitors are GRAS compounds. The one or more inhibitor compounds inhibit the enzymes responsible for rapid presystemic metabolism, thus allowing the bioactives (e.g., phenylephrine) to be more readily absorbed intact into the circulatory system.
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