3-{(3R, 4R)-4-Methyl-3-methyl-(7h-pyrrolo 2,3-d pyrimidin-4-yl )amino piperidin-1-yl) }-3-oxo propionitrile, pharmaceutical composition containing thereof and its use

摘要

In the present invention, there are described 3-{(3R, 4R)-4-Methyl-3-[methyl-(7h-pyrrolo [2,3-d] pyrimidin-4-yl )amino] piperidin-1-yl) }-3-oxo propionitrile and pharmaceutically acceptable salts of this compound, a pharmaceutical composition comprising these compounds as well as the use of these compounds, optionally in combination with at least one another agent, which modulates immunity system in mammals or with an anti-inflammatory agent for the preparation of a medicament for inhibition of protein kinases or Janus kinase (JAK3) in a mammal, including a human, for the preparation of a medicament for the treatment or prevention of a disorder or condition selected from organ transplant rejection, xeno transplantation, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, Type 1 diabetes and complications from diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, Crohn's disease, Alzheimer's disease and leukemia.