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Influenza virus-like particles (vlps) comprising hemagglutinin related to type a/california/04/09, and methods for producing the same
Influenza virus-like particles (vlps) comprising hemagglutinin related to type a/california/04/09, and methods for producing the same
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机译:包含与a /加利福尼亚/ 04/09型有关的血凝素的流感病毒样颗粒(vlps)及其生产方法
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摘要
A method for synthesizing influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of influenza HA of type A/California/04/09 in plants and the purification by size exclusion chromatography. The invention is also directed towards a VLP comprising influenza HA protein of type A/California/04/09 and plants lipids. The invention is also directed to a nucleic acid encoding influenza HA of type A/California/04/09 as well as vectors. The VLPs may be used to formulate influenza vaccines, or may be used to enrich existing vaccines.
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