PROCESS DEVELOPMENT OF OCUSERT LOADED WITH NANOSIZED MODEL ANTI ANXIETY AGENT USING LUFFA ACUTANGULA BIOPOLYMER FOR BRAIN SPECIFICITY

摘要

The current invention explores a novelistic approach for delivery of model anti anxiety agent for brain targeting via ocular route.Ocular region is enrich of nerve supply when a nanosized API was placed in a ocular region by suitably designing dosage form ocusert to placed in a ocular region.significant amount of the drug will reach to brain via Olfactory nerve,optic nerve,_Oculomotor Nerve,neural pathway.The same was confirmed by preliminary screening of API.Model Anti anxiety agent was targetted to brain by suitably nanosizing model anti anxiety agent by using a novel film former isolate from luffa acutangula by simplified economical process.The bio polymer was charecterized for physicochemical properties,SEM analysis,MASS analysis,IR analysis.The polymer was screened for it"s filmability ,emulsifiability, retartabiiity by designing suitable dosage form.The bio polymer was used as a film former for preparing bio ocuserts using nanosized model antianxiety agent and other co processing agent.The results revealed that significant amount of drug was reaching to brain for electing pharmacological action of model anti anxiety agent for 36(hr) .This platform can serve as a novelistic route for brain specificity for delivery.