A LIPOSOMAL COMPOSITION USEFUL FOR INHIBITING TUMOR GROWTH THROUGH RNA-INTERFERENCE USING LIPOSOMALLY ASSOCIATED CDC20 SIRNA

摘要

Liposomal compositions comprising of liposomes of guanidinylated cationic amphiphiles as the main lipid and cholesteroVl,2-dioleoyl-sn-glycero-3-phosphocholine (D0PC)Iaminopropyl polyethyleneglycol carbamyl-distearoylphosphatidyl-ethanolamine (DSPE-peg-NH2) as co-lipids are described. These liposomal compositions containing encapsulated or electrostatically complexed therapeutic small interfereing RNAs (siRNAs) against Cdc20, a key cell cycle regulator, inhibit solid tumor growth and melanoma tumor growth.