ISOLATED HUMAN OR HUMANIZED ANTIBODIES BINDING TO RECEPTORS KIR2DLI, -2, 3 BUT NOT KIR2DS4

摘要

Compositions and methods for regulating an immune response in a subject are described. More particularly, described arc human antibodies that regulate the activity of NK cells and allow a poteniiation of NK cell cytotoxicity in mammalian subjects, and antibodies having antigen-binding properties similar to those of human monoclonal antibody 1-7F9 or 14FI. Described also arc also fragments and derivatives of such antibodies, as well as pharmaceutical compositions comprising the same and their uses, particularly for use in therapy, to increase NK cell activity or cytotoxicity in subjects.