Derivatives of (1,2,4) triazolo 4,3-a quinoxaline inhibitors of phosphodiesterases

摘要

Relating to compounds of formula (i) wherein: R1 is piridilo phenyl 2 -, 3 - or 4 - piridilo piridilo, which are replaced with different Substituent in Ortho position of H a ligation to the structure of the main Chain; R2 is H, c1-c4 alkyl, optionally substituted with up to 2 halo ; R3, R4, R5 and R6 are independently h, halogen, CN, oC1-c4 alkyl, optionally substituted with up to 5 Halo, among others. Preferred compounds are: 8 - chlorine - 1 - (2 - chloro phenyl) - 4 - methyl - [1,2,4] triazolo [4,3-a] quinoxaline; 4-chloro-3 - (8 - chlorine - 4 - methyl - [1,2,4] triazolo [4,3-a] quinoxalin - 1 - il) phenol, among others.These compounds are inhibitors of phosphodiesterase 2 and / or 10, be helpful for the treatment of Alzheimer's disease, Mental Retardation, Neurotic disorders, Schizophrenia, Epilepsy