DERIVATIVES OF TRIAZOLYL-IMIDAZOPYRIDINE AND OF THE TRIAZOLYLPURINES USEFUL AS LIGANDS OF THE ADENOSINE A2a? RECEPTOR AND THEIR USE AS MEDICAMENTS

摘要

Compounds of formula (I) wherein: X is N; RSUB1 /SUBis CSUB1/SUB-CSUB6 /SUBlinear or branched alkyl or CSUB1/SUB-CSUB6 /SUBlinear or branched alkenyl; RSUB2 /SUBis hydrogen, CSUB1/SUB-CSUB6 /SUBlinear or branched alkyl or CSUB1/SUB-CSUB6 /SUBlinear or branched alkenyl, CSUB6/SUB-CSUB14 /SUBaryl or CSUB6/SUB-CSUB14 /SUBaryl(CSUB1/SUB-CSUB6/SUB) linear or branched alkyl or CSUB6/SUB-CSUB14 /SUBaryl(CSUB1/SUB-CSUB6/SUB) linear or branched alkenyl, with the aryl group optionally substituted by one or more substituents, either the same or different, selected from the group consisting of halogen, hydroxy, CSUB1/SUB-CSUB6 /SUBalkoxy linear or branched or CSUB1/SUB14 CSUB6 /SUBalkenyloxy linear or branched, amino, optionally mono- or disubstituted with CSUB1/SUB-CSUB6 /SUBlinear or branched alkyl; RSUB3 /SUBis NHSUB2/SUB, NHRSUB4/SUB; RSUB4 /SUBis CSUB1/SUB-CSUB6 /SUBalkyl or CSUB1/SUB-CSUB6 /SUBhydroxyalkyl, CSUB1/SUB-CSUB3 /SUBalkoxyalkyl, amino(CSUB1/SUB-CSUB6/SUB)alkyl, where the amino group is optionally substituted with one or two CSUB1/SUB-CSUB3 /SUBlinear or branched alkyl groups, or with one or two CSUB2/SUB-CSUB3 /SUBalkenyl groups CSUB6/SUB-CSUB14 /SUBaryl or CSUB6/SUB-CSUB14 /SUBaryl(CSUB1/SUB-CSUB6/SUB)alkyl, with the aryl group optionally substituted by one or more substituents, either the same or different, selected from the group consisting by halogen, hydroxy, CSUB1/SUB-CSUB6 /SUBalkoxy linear or branched or CSUB1/SUB-CSUB6 /SUBalkenyloxy linear or branched, amino, mono- or di-substituted with CSUB1/SUB-CSUB6 /SUBalkyl linear or branched or CSUB1/SUB-CSUB6 /SUBalkenyl linear or branched; and their pharmaceutically acceptable salts. These compounds are antagonists of the adenosine ASUB2a /SUBreceptor and useful as medicaments, in particular for the treatment of Parkinson's disease.