method for preparation of tablets containing the firampicine in combination with isoniazid, pyrazinamide, ethambutol, and possibly the

摘要

the present invention relates to a process for preparing a pharmaceutical composition in the form of a tablet containing in association at least the following active ingredients: rifampicin, isoniazid, and pyrazinamide. advantageously, the pharmaceutical composition includes at least one fourth estate: ethambutol or one of its salts.in particular, the preparation process according to the present invention is prepared by wet granulation of isoniazid, pyrazinamide and ethambutol, possibly. the composition obtained is used in a composition of fixed dose combination of 3 or 4 active ingredients mentioned above, tb therapeutic activity, able to be administered by the oral route.