METHOD FOR TREATING AND PREVENTING THROMBOPHILIA PREDOMINANTLY IN GESTATION AND POST PARTUM

摘要

A method for treating and preventing thrombophilia predominantly in gestation and post partum comprises anticoagulant therapy on an outpatient basis with 50-75 mg of tabletted Pentosan polysulfate SP 54 as herbal-derived heparinoid in the mode of the specified daily dose until the normalization of the physiological parameters of hemostasis. In addition, in the first trimester prior to the beginning of the treatment, D-dimer content is assayed in the hospital as a marker of thrombophilia. Furthermore, the concentration of the soluble fibrin monomer complexes in the blood and the body mass of the pregnant patient are taken into account. When the accumulation of D-dimer or soluble fibrin monomer complexes exceeds 0.5 µgFEU/mL or 0.2 mg/L, respectively, Fraxiparin is injected subcutaneously in a volume of 0.3-0.6 mL daily under control of platelet count and calcium content every 5 and 14 days, correspondingly, until the normalization of thrombinemia values. When the accumulation of D-dimer or soluble fibrin monomer complexes exceeds 1.5 µgFEU/mL or 0.6 mg/L, respectively, or body mass index exceeds 34.9 kg/m, Pentosan polysulfate SP 54 (2 daily doses) is administered together with Calcemin advance as stimulator of phosphorus-calcium metabolism.