Method and composition to protect neuronal tissue from lesions induced by elevated glutamate levels

摘要

Glutamate pyruvate transaminase (GPT) and pyruvate for use in the treatment of a medical condition associated with elevated extracellular glutamate levels in the brain selected from the group consisting of cerebral anoxia, cerebral ischemia, stroke, perinatal brain injury, traumatic brain injury, bacterial meningitis , subarachnoid hemorrhage, migraine, stress, hemorrhagic shock, epilepsy, acute liver failure, glaucoma, HIV, dementia, amyotrophic lateral sclerosis (ALS), spastic ailments, open heart surgery, aneurysm surgery, coronary artery bypass graft and disease Alzheimer's disease and where said GPT is formulated for parenteral administration.