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Use of IL-6 in the preparation of pharmaceutical compositions to treat and prevent liver lesions

机译:IL-6在制备用于治疗和预防肝损伤的药物组合物中的用途

摘要

Use of IL-6 or a mutein, isoform, fused protein, functional derivative, active fraction or salt thereof, in the manufacture of a medicine for the treatment of liver cirrhosis treated by liver resection, said medicine optionally comprising a pharmaceutically acceptable vehicle , wherein the medicament is for administration at a dose ranging from 0.1 to 10 mcg / kg; and wherein additionally the functional derivative comprises at least one polyethylene moiety attached to one or more functional groups that occur in the form of one or more side chains at the amino acid residues and the mutein, isoform, fused protein, functional derivative, fraction active or salt is capable of binding to the gp80 IL-6 binding site.
机译:IL-6或其突变蛋白,同工型,融合蛋白,功能性衍生物,活性部分或盐在制备通过肝切除术治疗肝硬化的药物中的用途,所述药物任选地包含药学上可接受的载体,其中所述药物以0.1至10mcg / kg的剂量给药;其中功能衍生物还包含至少一个连接至一个或多个功能基团的聚乙烯基部分,该基团以一个或多个侧链的形式出现在氨基酸残基和突变蛋白,同工型,融合蛋白,功能衍生物,活性部分或盐能够结合gp80 IL-6结合位点。

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