Process for the manufacture of a stable soft gel capsule containing microencapsulated probiotic bacteria

摘要

A manufacturing process of a soft gel capsule containing microencapsulated probiotic bacteria, comprising the steps of: (a) providing microencapsulated probiotic bacteria with at least one coating comprising at least one plant lipid having a melting point between approximately 35 ° C and approximately 75 ° C; (b) suspend microencapsulated probiotic bacteria in a suspension formulation to make a filler; (c) mixing the filling at an intensity less than 3,000 rpm, and a temperature below 33 ° C to produce a mixed filling; (d) reduce the size of the particles and separate the particles of the microencapsulated probiotic bacteria in the mixed filler to make a deagglomerated filler having a controlled particle size suitable for encapsulation; and (e) encapsulate the deagglomerated filler in a soft gel capsule, where the integrity of the coating of the microencapsulated probiotic bacteria is maintained.