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Compositions comprising 4- (heterocycloalkyl) benzene-1,3-diol derivatives with tyrosinase enzyme inhibitory activity

机译:包含具有酪氨酸酶抑制活性的4-(杂环烷基)苯-1,3-二醇衍生物的组合物

摘要

Cosmetic composition comprising, in a cosmetically acceptable vehicle, at least one compound of general formula (I) below: in which: R1, R2, R3 and R4, which may be identical or different, represent: - a hydrogen, - a C1-C4 alkyl radical, - a hydroxymethyl, a hydroxyethyl, - a (C1-C4 alkoxy) carbonyl, - a C1-C4 alkoxy, - a hydroxyl, or R1 and R2 are linked together and form a ring of carbons containing 5 or 6 carbon atoms, with the carbon atom to which they are attached, and R3 and R4, which may be identical or different, represent: - a hydrogen, - a C1-C4 alkyl radical, or R1 and R4 are linked together and form a chain - (CH2) 2- or - (CH2) 3-, and R2 and R3, which may be identical or different, represent: - a hydrogen, - a C1-C4 alkyl radical, X represents an oxygen atom or a sulfur atom, Y represents a hydrogen, a chlorine atom or a fluorine atom, m can have the value 1 or 2, and np it can have the value 0 or 1, and when n = 0, then m = 1 or 2, and when n = 1, then m = 1, and also the salts of the compounds of general formula (I), and the enantiomeric forms thereof.
机译:在化妆品可接受的媒介物中包含至少一种通式(I)的化合物的化妆品组合物:其中:R 1,R 2,R 3和R 4可以相同或不同,它们表示:-氢,-C1- C 4烷基,-羟甲基,羟乙基,-(C 1 -C 4烷氧基)羰基,-C 1 -C 4烷氧基,-羟基或R 1和R 2连接在一起并形成含5或6个碳的碳环R3和R4可以相同或不同,并带有与其相连的碳原子,它们表示:-氢,-C1-C4烷基或R1和R4连接在一起并形成链- (CH 2)2-或-(CH 2)3-,且R 2和R 3可以相同或不同,表示:-氢,-C 1 -C 4烷基,X代表氧原子或硫原子,Y表示氢,氯原子或氟原子,m的取值为1或2,np的取值为0或1,当n> = 0时,则m> = 1或2,当n > = 1,然后m> = 1,然后al因此通式(I)的化合物的盐及其对映体形式。

著录项

  • 公开/公告号ES2506265T3

    专利类型

  • 公开/公告日2014-10-13

    原文格式PDF

  • 申请/专利权人 GALDERMA RESEARCH & DEVELOPMENT;

    申请/专利号ES20120182351T

  • 发明设计人 BOITEAU JEAN-GUY;PASCAL JEAN-CLAUDE;

    申请日2009-12-02

  • 分类号A61K31/341;A61K31/351;A61K31/381;A61K31/382;A61Q19/02;C07D307/12;C07D309/06;C07D333/16;C07D335/02;

  • 国家 ES

  • 入库时间 2022-08-21 15:54:56

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