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PKC inhibitors for the treatment of B-cell lymphoma having chronic active B-cell-receptor signalling
PKC inhibitors for the treatment of B-cell lymphoma having chronic active B-cell-receptor signalling
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机译:PKC抑制剂用于治疗具有慢性活性B细胞受体信号转导的B细胞淋巴瘤
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摘要
The present invention demonstrates that chronic active BCR signaling through CD79A/B confers a strong dependence on downstream PKCb kinase signaling. Hence, provided herein is a method for inhibiting the growth of B-cell lymphoma having chronic active B-cell-receptor signaling, or inhibiting the growth of cancers with molecular lesions that lead to chronic active BCR signaling, by administering to a patient in need of such treatment a therapeutically effective amount of a PKC inhibitor or a use of a PKC inhibitor to inhibit the growth of B-cell lymphoma having chronic active B-cell-receptor signaling or to inhibit the growth of cancers with molecular lesions that lead to chronic active BCR signaling.
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