首页>
外国专利>
INHIBITION OF LEUKEMIC STEM CELLS BY PP2A ACTIVATING AGENTS
INHIBITION OF LEUKEMIC STEM CELLS BY PP2A ACTIVATING AGENTS
展开▼
机译:PP2A活化剂对白血病干细胞的抑制作用
展开▼
页面导航
摘要
著录项
相似文献
摘要
A method of inhibiting the growth of leukemic hematopoietic stem cells in a subject with leukemia is described. The method includes administering a therapeutically effective amount of a composition including a compound of formula I: I wherein R1 is independently selected from hydrogen and methyl; R2 is selected from the group consisting of 4,8-dimethyl-non-1-enyl, 4,8-dimethyl-nonyl, non-1-enyl, and nonanyl groups; X is a carboxyl, phosphonic, or sulfonic moiety, and n is an integer from 1 to 6, or a compound of Formula II: II wherein R1 is a C6-C12 alkyl or C6-C12 alkoxy group; R2 is independently selected from the group consisting of hydrogen, methoxy, and hydroxyl; and R3 is an alkyl or cycloalkyl group; or a pharmaceutically acceptable salt thereof.
展开▼
机译:描述了在白血病受试者中抑制白血病造血干细胞生长的方法。该方法包括给予治疗有效量的组合物,该组合物包括式I的化合物:其中R 1 Sup>独立地选自氢和甲基; R 2 Sup>选自4,8-二甲基-壬-1-烯基,4,8-二甲基-壬基,壬-1-烯基和壬基; X是羧基,膦酸或磺酸部分,n是1至6的整数,或式II:II的化合物,其中R 1 Sup>是C 6 Sub> -C 12 Sub>烷基或C 6 Sub> -C 12 Sub>烷氧基; R 2 Sup>独立地选自氢,甲氧基和羟基; R 3 Sup>为烷基或环烷基;或其药学上可接受的盐。
展开▼