MARKER FOR DETERMINING THE THERAPEUTIC POTENTIAL OF MESENCHYMAL STEM CELLS, AN INHIBITOR OF THE MARKER FOR THERAPEUTIC USE AND STEM CELLS WITH LOW EXPRESSION OF THE MARKER FOR THERAPEUTIC USE

摘要

The invention relates to methods for determining the therapeutic potential and immunoregulatory capacity of stems cells, based on expression levels of microRNA miR-335. This determination can be used as a criterion for the release of groups of stem cells for therapeutic use. In addition, the invention also relates to in vitro methods for increasing the immunoregulatory capacity of a stem cell, in which said methods comprise treating the stem cell with an miR-335 inhibitor. Finally, the invention relates to therapeutic methods and uses for treating a patient with an autoimmune disease, an inflammatory disease, graft-versus-host disease or a disease requiring transplant tolerance induction or regeneration and/or repair of tissue, said therapeutic methods and uses comprising the administration of a stem cell having reduced miR-335 levels of expression and/or activity.