DOMINANT NEGATIVE TRANSCRIPTION FACTOR FOR ANTAGONIZING ONCOGENIC TRANSCRIPTION FACTORS VIA MULTIMERIZATION

摘要

The present invention teaches compositions, methods and kits for treating or preventing cancer in a subject by using a dominant negative transcription factor and/or a multimerization adaptor. The invention teaches that the dominant negative transcription factor can antagonize an oncogenic transcription activator and can cause cell cycle arrest and cell death in a cancer cell. The invention further teaches delivering the inventive compositions by a variety of mechanisms, including: transfection, a virus-based system, and using a protein-transduction- domain moiety fused to the inventive dominant negative transcription factor.