MATERIALS AND METHODS USEFUL TO TREAT NEUROBLASTOMAS AND PHEOCHROMOCYTOMAS

摘要

Methods for affecting one or more of: proliferation, migration and invasion of tumor cells are described. One method includes contacting the tumor cell with an effective amount of a composition such as tianeptine. Described herein are results showing that tianeptine causes apoptosis by increasing microtubule bundling in neuroblastoma and pheochromocytoma cells. In addition, tianeptine blocks growth of neuroblastoma and pheochromocytoma by inducing specific and rapid degradation of cytoplasmic dynein, a microtubule motor protein that arranges the mitotic spindles during mitosis.