ADMINISTERING INHIBITORS OF TGFBETA SIGNALING, BENZOTHIAZEPINE DERIVATIVES OR COMBINATIONS THEREOF TO IMPROVE MUSCLE FUNCTION IN CANCER PATIENTS

摘要

Methods and compositions useful for reducing loss of muscle function caused by bone metastasis in a subject with cancer. In certain embodiments, the methods of the present invention include administering to a cancer patient compositions that include a therapeutically or prophylactically effective amount of one or more inhibitors of TGFbeta signaling, one or more benzothiazepine derivatives, or combinations thereof. Also, uses of such compositions for a medicament for such treatments.