MACROPHAGE-DERIVED MATRIX VESICLES: AN ALTERNATIVE MECHANISM FOR MICROCALCIFICATION IN ATHEROSCLEROTIC PLAQUES

摘要

The invention relates to methods for decreasing, inhibiting, preventing, or reducing matrix vesicle induced calcification by inhibiting the amount or formation of a complex comprising phosphatidylserine (PS), annexin II, annexin V or VI, and S100A9 or S100A12 in a macrophage.