DENDRITIC PIC MICELLES WITH BIOACTIVE PROTEINS

摘要

Dendritic PIC micelles with bioactive proteins. The invention relates to a Polyion Complex (PIC) polymeric micelle formed by interaction between a bioactive protein and a dendritic block copolymer of opposite charge. The conventional low stability of PIC micelles with bioactive proteins vis-à-vis ionic strength is offset in the present invention by the stability provided by the dendritic block. The overall process for preparing these micelles is facilitated by the simplicity of the drendritic block copolymer synthesis.