Synthesis and Photophysical Property of Polyion Complex Micelle Incorporating Phthalocyanine Zinc(II) Bearing Benzyl Ether Dendritic Substituents with Nitro-terminal Group

摘要

A new phthalocyanine Zinc(II) bearing benzyl ether dendritic substituents with nitro-terminal group: tetra-{3,5-[di-(4-nitro benzyloxy) benzyloxy]} Phthalocyanine Zinc(II) (ZnPc(NO_2)_8), was synthesis and characterized by 1R, ~1HNMR, MALDI-TOF-MS and UV/Vis. UV/Vis spectra of ZnPc(NO_2)_8 exhibited characteristic absorption peaks at 290, 350 and 680 nm, and fluorescence emission peak was at 692 nm with a quantum yield at 0.20 in dimethylsulfoxide (DMSO). The polymeric nanoparticle ZnPc(NO_2)_8@MPEG-PLGA was formed between the amphiphilic block copolymer poly(ethylene glycol)-polylactic and polyglyctic acids (PEG-PLGA) and ZnPc(NO_2)_8, ZnPc(NO_2)_8@MPEG-PLGA formed a core-shell-type nanoparticle with diameter about 70 nm. UV/Vis spectra and fluorescence emission spectra of ZnPc(NO_2)8@MPEG-PLGA were obviously lower than that of free ZnPc(NO_2)_8 in buffer solution, and with varying degrees of redshift. ZnPc(NO_2)8@MPEG-PLGA would be a promising third-generation photosensitizer for PDT.