INTERMEDIATES FOR SYNTHESIZING TREPROSTINIL AND PREPARATION METHOD THEREOF AS WELL AS THE PREPARATION METHOD OF TREPROSTINIL THEREBY

摘要

The present invention relates to the preparation of intermediates of treprostinil, a preparation method for same, and the preparation of treprostinil thereby. Specifically, the invention relates to the compound of formula (VI), the preparation thereof and the application of said compound for the synthesis of treprostinil (as represented by formula (I)). The method for the preparation of treprostinil comprises: obtaining the compound of formula (III) by means of reducing the compound of formula (VI) and deprotecting the hydroxy group thereof; reacting said compound of formula (III) with chloroacetonitrile followed by hydrolysis to obtain the treprostinil of formula (I). The present method is simple, yields high rates of synthesis, and is suitable for industrial production.