首页> 外国专利> DIRECT SYNTHESIS OF 18F-FLUOROMETHOXY COMPOUNDS FOR PET IMAGING AND THE PROVISION OF NEW PRECURSORS FOR DIRECT RADIOSYNTHESIS OF PROTECTED DERIVATIVES OF O-(18FFLUOROMETHYL)TYROSINE

DIRECT SYNTHESIS OF 18F-FLUOROMETHOXY COMPOUNDS FOR PET IMAGING AND THE PROVISION OF NEW PRECURSORS FOR DIRECT RADIOSYNTHESIS OF PROTECTED DERIVATIVES OF O-(18FFLUOROMETHYL)TYROSINE

机译：直接合成18 F-氟乙氧基化合物用于PET成像，并提供直接放射合成邻位[[18F]氟乙氧基]酪氨酸衍生物的新前体

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摘要

The invention describes novel direct synthesis methods for converting a precursor into a PET-tracer with a ¹⁸F-fluoromethoxy-group. The invention is also directed to novel and stable precursors for the direct radiosynthesis of protected derivatives of O- ([¹⁸F]Fluoromethyl) tyrosines.

机译：本发明描述了用于将前体转化为具有^{18 F-氟甲氧基的PET-示踪剂的新颖的直接合成方法。本发明还涉及用于直接放射性合成 O-（[[Sup> 18 F]氟甲基）酪氨酸的保护衍生物的新颖且稳定的前体。} 展开▼

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公开/公告号EP2751087A1

专利类型

公开/公告日2014-07-09

原文格式PDF

申请/专利权人 PIRAMAL IMAGING SA;
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申请/专利号EP20120732636

发明设计人 BRUMBY THOMAS;GRAHAM KEITH;KRÜGER MARTIN;
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申请日2012-06-29

分类号C07D249/04;C07D249/18;C07D471/04;

国家 EP

入库时间 2022-08-21 15:45:28

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1. 作为诊断成像剂的18F氟－苯甲酰标记的生物学活性化合物以及苯并三唑－1－基氧基－苯甲酰，2,5－二氧代－吡咯烷－1－基氧基)苯甲酰和三甲铵基－苯甲酰前体 [P] . 中国专利： CN101616694A . 2009-12-30

2. 由α，β不饱和羧酸和酮类化合物直接合成含不饱和烯的α-酰氧基酮衍生物的方法 [P] . 中国专利： CN106242968B . 2018.11.06

3. Direct synthesis of 18F-fluoromethoxy compounds for pet imaging and the provision of new precursors for direct radiosynthesis of protected derivatives of o-( 18Ffluoromethyl) tyrosine [P] . AU2012277730A1 . 2014-01-23

机译：直接合成用于宠物成像的18F-氟甲氧基化合物，并提供新的前体以直接放射性合成邻位[[18F]氟甲基）酪氨酸的保护衍生物

4. DIRECT SYNTHESIS OF 18F-FLUOROMETHOXY COMPOUNDS FOR PET IMAGING AND THE PROVISION OF NEW PRECURSORS FOR DIRECT RADIOSYNTHESIS OF PROTECTED DERIVATIVES OF O-(18FFLUOROMETHYL) TYROSINE [P] . 韩国专利： KR20140063577A . 2014-05-27

机译：直接合成18 F-氟代乙氧基化合物以用于PET成像，并提供直接放射合成邻-（18-氟代氟乙基）酪氨酸的衍生物的新前驱物

5. DIRECT SYNTHESIS OF 18F-FLUOROMETHOXY COMPOUNDS FOR PET IMAGING AND NEW PRECURSORS FOR DIRECT RADIOSYNTHESIS OF PROTECTED DERIVATIVES OF O-(18FFLUOROMETHYL) TYROSINE [P] . CA2840768A1 . 2013-01-03

机译：直接合成18 F-氟乙氧基化合物用于PET成像和直接放射合成邻位[[18F]氟乙氧基]酪氨酸衍生衍生物的新前体

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