Facile fully automated radiosynthesis and quality control of O-(2-[F-18] fluoroethyl)-L-tyrosine ([F-18]FET) for human brain tumor imaging

摘要

O-(2-[F-18]Fluoroethyl)-L-tyrosine ([F-18]FET) has become one of the most successful amino acid tracers for human brain tumor imaging with positron emission tomography (PET). Facile fully automated radiosynthesis and quality control (QC) of [F-18]FET using our home-built automated multi-purpose F-18-radiosynthesis module are described. [F-18]FET was produced in 75-80 min overall synthesis time with 20-25% radiochemical yield decay corrected to end of bombardment (EOB), based on H[F-18]F. The radiochemical and enantiomeric purities were >99%, and the molar activity (A(m)) was 189-411 GBq/mu mol at EOB. The [F-18]FET dose meets all QC criteria for clinical use, and is suitable for clinical PET study of brain tumor.