Method to screen for the teratogenic potential of substances

摘要

The present invention relates to co-crystal forms of a bacterial cereblon homologue together with thalidomide, crystal structure information obtained from them, methods of preparing such co-crystal forms. The invention refers further to an in vitro method to analyze the teratogenic potential of substances, preferably pharmaceutically active substances, via their binding to the protein cereblon, a cellular target of thalidomide, and refers to the substrate 1-(N-2-MANT-imidoethyl)-uracil as well as a mutant bacterial cereblon homologue from Magnetospirillum gryphiswaldense both compounds of the inventive method.