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SUSTAINED-RELEASE COMBINATION PREPARATIONS FOR THE TREATMENT OF DIABETES MELLITUS HAVING ENHANCED COMPLIANCE AND PREPARATION METHOD THEREOF
SUSTAINED-RELEASE COMBINATION PREPARATIONS FOR THE TREATMENT OF DIABETES MELLITUS HAVING ENHANCED COMPLIANCE AND PREPARATION METHOD THEREOF
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机译:具有增强顺应性的治疗糖尿病的缓释组合制剂及其制备方法
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摘要
The present invention relates to a sustained release combination formulation with improved diabetes for treating diabetes and a method for manufacturing the same and, more specifically, to a sustained release combination formulation for treating diabetes, which is characterized by using a carbomer as a sustained release carrier and a method for manufacturing the same. The sustained release combination formulation comprises: an inner layer containing metformin or a pharmaceutically acceptable salt thereof, a sustained release carrier, and a pharmaceutically acceptable excipient; a drug-free intermediate layer containing water soluble polymers; and an outer layer containing a sulfonylurea-based drug and a release controller. According to the present invention, the sustained release combination formulation for treating diabetes comprising the inner layer containing metformin, the intermediate layer, and the outer layer containing the sulfonylurea-based drug has the same release pattern as amaryl Mex which is an existing combination formulation for treating diabetes, using the carbomer as a sustained release carrier. Also, the sustained release combination formulation does not cause gastrointestinal disorders because the sustained release carrier is almost decomposed within 24 hours and enhances drug compliance through easy administration because the weight of the inner layer is minimized and the size of tablets is reduced. [Reference numerals] (AA) Amaryl Mex;(BB) Example 1
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