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Sustained-Release combination preparations for the treatment of diabetes mellitus having enhanced compliance and preparation method thereof
Sustained-Release combination preparations for the treatment of diabetes mellitus having enhanced compliance and preparation method thereof
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机译:具有增强顺应性的治疗糖尿病的缓释组合制剂及其制备方法
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摘要
The present invention relates to sustained-release complex preparations for the treatment of diabetes with improved drug compliance and to a method for preparing same. More particularly, the present invention relates to sustained-release complex oral preparations for the treatment of diabetes, which comprise: a) an inner layer that includes Metformin or pharmaceutically acceptable salts thereof, sustained-release carriers and a pharmaceutically acceptable excipient; b) an intermediate layer that does not include drugs and that includes a water-soluble polymer; and c) an outer layer that includes sulfonylurea-based drugs and a control release formulation, wherein Carbomer is used as the sustained-release carriers. According to the present invention, complex preparations for the treatment of diabetes, comprising the inner layer including Metformin, the intermediate layer and the outer layer including sulfonylurea-based drugs, use Carbomer as the sustained-release carriers of the inner layer, thus exhibiting the same release pattern as that of Amaryl Mex which has been used in conventional complex preparations for the treatment of diabetes. Furthermore, the greater part of the sustained-release carriers is decomposed after 24 hours, thus avoiding gastrointestinal tract disorders. The weight of the inner layer is minimized to reduce the size of a tablet to allow for ease of medicine taking, thus improving drug compliance of a patient.
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