A NOVEL ANTIBODY INHIBITING OSTEOCLASTOGENESIS

摘要

The present invention relates to an antibody capable of inhibiting osteoclast differentiation, and more particularly, to a RANKL(receptor activator of NF-B ligand)-specific antibody capable of inhibiting RANKL-induced osteoclast differentiation, a polynucleotide coding for the antibody, an expression vector containing the polynucleotide, a transformant transformed with the expression vector, a manufacturing method of the RANKL-specific antibody using the transformant, a preventive and therapeutic composition for bone diseases containing the RANKL-specific antibody as an effective component, a composition for inhibiting osteoclast differentiation containing the RANKL-specific antibody as an effective component, and an inhibiting method for osteoclast differentiation using the same. The RANKL-specific antibody in the present invention is an antibody which binds to human and mouse RANKL. An antigen-recognition of RANKL can be useful in any application and is used in preclinical and clinical studies. Bone diseases caused by the imbalance of osteoclast can be treated by inhibiting osteoclast differentiation by suppressing the activation of RANKL capable of stimulating osteoclast differentiation. The present invention is useful in developing a therapeutic agent for bone-related diseases.