A novel antibody inhibiting osteoclastogenesis

摘要

The present invention relates to an antibody capable of inhibiting osteoclast differentiation. More specifically, the present invention relates to a RANKL-specific antibody capable of inhibiting RANKL (receptor activator of NF-κB ligand) -induced osteoclast differentiation, A polynucleotide encoding an antibody, an expression vector containing the polynucleotide, a transformant into which the expression vector is introduced, a method for producing the RANKL-specific antibody using the transformant, a method for producing the RANKL-specific antibody As an active ingredient, a composition for inhibiting osteoclast differentiation comprising the RANKL-specific antibody as an effective ingredient, and a method for inhibiting osteoclast differentiation using the composition will be. The RANKL-specific antibody of the present invention is an antibody that specifically binds to RANKL of human and mouse, and is characterized by its cross-specificity to mouse and human RANKL, And can be useful for preclinical and clinical studies. In addition, since the activity of RANKL promoting osteoclast differentiation is inhibited and osteoclast differentiation is inhibited, osteoclastic diseases caused by osteoclast imbalance can be treated, and thus it can be widely used for the development of therapeutic agents for bone related diseases There will be.