Serum biomarker proteins predictive of the resistance to chemotherapy in breast cancer

摘要

PURPOSE: A biomarker for diagnosing resistance to a chemotherapeutic agent in a patient with breast cancer is provided to enable an individual patient to select a treatment direction and to enhance survival rate of the patient without recurrence. CONSTITUTION: A composition for diagnosing resistance to a chemotherapeutic agent in a patient with breast cancer contains antibodies which specifically bind to proteins selected among a group consisting of alpha-2-HS-glycoprotein, apolipoprotein B, complement component 3, complement component 9, ceruloplasmin, and orosomucoid 1. A kit for diagnosing resistance to a chemotherapeutic agent contains the antibodies. A microarray for diagnosing resistance to a chemotherapeutic agent contains the antibodies.