Hydrophilic/hydrophobic patterned biochips for on chip MALDI-TOF MS

摘要

The present invention is a hydrophilic / hydrophobic patterned by the bio-chip , and this method for producing a target substance by using this is directed to a method for the detection or analysis . Specifically , (1 ) forming a metal grid pattern on the substrate, (2) forming a self-assembled thiol monolayer is mixed in the metal surface ; And (3) , including the step of attaching the molecule to the hydrophobic substrate may be prepared biochip with a patterned hydrophilic / hydrophobic , bio-chip of the present invention are reliably and high -mass spectrometry of the protein of interest from a mixture of multi- protein can be used for SPR imaging analysis . ;