MULTIFUNCTIONAL POLY(LACTIDE-CO-GLYCOLIDE) NANOPARTICLES FOR LUMINESCENCE/MAGNETIC RESONANCE IMAGING AND PHOTODYNAMIC THERAPY, AND METHOD FOR PREPARING THE SAME

摘要

The present invention relates to multifunctional PLGA nanoparticles for fluorescence/MR imaging and photodynamic therapy, and a method for preparing the same, wherein the multifunctional PLGA nanoparticles are prepared by combining a hydrophilic biocompatible polymer and a photo-sensitizer with a PLGA polymer having excellent biocompatibility. In addition, the present invention relates to a photo-dynamic therapy method using the PLGA nanoparticles. The multifunctional PLGA nanoparticles according to the present invention can have excellent biocompatibility and biodegradability, increase particle stability in the blood to improve drug efficiency, and maximize the therapy effect. Further, the multifunctional PLGA nanoparticles according to the present invention can provide high-resolution MR images of cancer cells and perform selective photo-dynamic treatment on only cancer cells through local irradiation of light, thereby maximizing cancer therapy effects.