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Pharmaceutical formulation of carboxamide HIV integrase inhibitors containing a release rate controlling composition
Pharmaceutical formulation of carboxamide HIV integrase inhibitors containing a release rate controlling composition
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机译:含有释放速率控制组合物的羧酰胺HIV整合酶抑制剂的药物制剂
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摘要
Pharmaceutical formulations suitable for oral administration in solid dosage forms are described. The compositions comprise an effective amount of a base salt of a compound of Formula I and a release rate controlling composition comprising a solubilizing agent, a gelling agent, and a water soluble filler; wherein Formula I is: wherein R 1 , R 2 , R 3 and R 4 are defined herein. The formulations are suitable for use in the inhibition of HIV integrase, the treatment and prophylaxis of HIV infection, and the treatment, prophylaxis and delay in the onset of AIDS.
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