Aminocyclopentane carboxylic acid-containing cyclo RGD derivatives, a process for the preparation thereof and a PET contrast agent comprising the same

摘要

the invention are selective for cancer cells to known cyclo RGDK peptide (cyclo Arg-Gly-Asp- Lys) of lysine and aspartic acid between amino cyclopentane carboxylic acid (ACP) cyclohexane obtained by inserting a peptide bond by the ACP-RGDK, by way of a cycloalkyl ACP-RGDK ligand radioisotope ⁶⁴ Cu ^{2 +} and novel compounds that combine PET contrast agent , the production of the novel intermediate compounds , the preparation thereof, and provides a PET contrast agent comprising the novel compounds . ;