PHARMACEUTICAL COMPOSITION COMPRISING THE EXTRACT OF ANGELICA GIGAS NAKAI AS AN EFFECTIVE COMPONENT FOR PREVENTION OR TREATMENT OF THROMBOSIS AND HEALTH FUNCTIONAL FOOD COMPRISING THE SAME

摘要

The present invention relates to a pharmaceutical composition and a health functional food for preventing or treating thrombosis, comprising an extract of Angelica gigas nakai as an active ingredient, and more particularly, to a pharmaceutical composition for preventing or treating thrombosis, comprising an ethanol extract of Angelica gigas nakai as an active ingredient, and a health functional food comprising the extract. The extract of Angelica gigas nakai as an active ingredient of the pharmaceutical composition and the health functional food for preventing or treating thrombosis according to the present invention, as proved through examples of the present specification, is produced by extracting a root portion of Angelica gigas nakai with ethanol or the like to prepare an extract and then performing sequential fractionation on the extract using hexene, ethyl acetate, and butanol. Of these, the butanol fraction exhibiting anti-thrombotic activity through an excellent blood coagulation inhibiting effect can efficiently inhibit thrombus generation and can be used for preventing and treating thrombosis such as ischemic stroke and hemorrhagic stroke through improvement of blood circulation. In particular, the extract of Angelica gigas nakai according to the present invention has no acute oral toxicity, retains excellent thermal stability, and has no loss in blood coagulation inhibition and activation effects even in an acidic condition of pH 2 and in the plasma, so that the extract can be processed into various types of an extract, a powder, a pill, and a tablet and thus be taken at any time. Accordingly, the present invention is very useful for the pharmaceutical industry and the food industry.