METHOD OF DETECTING AMPLIFICATION OR DELETION IN GENOMIC DNA FRAGMENT

摘要

the present invention, more accurate detection may also be sensitive to the number in CGH method, CGH microarray especially to provide a method to challenge. ; (a) the genome of the inspection object is a blood cell-derived DNA fragment to the genomic DNA fragment experimental formula (1) in any of the labeling substance or the labeling substance represented by the general formula (2) represents labeled with a labeling substance of the side, and the control genomic fragment as a reference for detecting the difference between the blood and the other to test genomic DNA fragment labeled with a marker and, (b) P-labeled genomic DNA fragments with a labeled control experiment the genomic DNA fragments, blood test genomic fragments and genomic fragments and competitively in contrast to the sample hybridizes to a nucleic acid comprising a nucleotide sequence for detecting the difference between, (c) obtained by the fluorescence intensity as an index, blood tests genome A method for detecting amplification or deletion of the DNA fragment, and the following general formula (1) with the nucleotide residues labeled with a labeling substance represented by comprising a labeled nucleotide residues to the labeling substance represented by the general formula (2), the method Kit for. ; The genomic DNA fragments, nucleotides, marker