PRESCRIBED COATED PHARMACEUTICAL COMPOSITIONS AND TABLETS, AND ALSO PRODUCTION METHODS

摘要

1. A pharmaceutical composition comprising compressible coated microparticles comprising: a. drug particles containing the drug and / or its pharmaceutically acceptable salt, ester, polymorph or solvate b. at least one modified release membrane layer comprising a water-insoluble polymer material located on top of the cores comprising the drug; c. an extrudable coating layer containing a non-polymer sweetener. 2. The pharmaceutical composition of claim 1, wherein said modified release membrane layer is applied to increase weight from about 5% to about 50% by weight of the total weight of the pressed coated microparticles. The pharmaceutical composition of claim 1, wherein said modified release membrane layer is a taste mask layer, wherein said taste mask layer is applied to increase weight from about 5% to about 50% by weight of the total weight of the coated coated microparticles. . The pharmaceutical composition according to claim 3, wherein said taste masking layer further comprises a stomach-soluble blowing agent, wherein the ratio of water-insoluble polymer material to the stomach-soluble blowing agent in said layer varies from about 95: 5 to 50:50, and the overall layer applied to increase weight from about 5% to about 50% by weight of the total weight of the pressed coated microparticles, and where the specified layer masking the taste, effectively masks the taste of the drug and / or its pharmacy evticheski acceptable salt, ester or Solva