METHOD OF ASSESSMENT OF BLOOD coagulation system of patients in critical condition

摘要

A method of estimating the state of the blood coagulation system of patients in critical condition, consisting in that assess the mechanical properties of a blood sample to the extent of clot formation in real-time by thromboelastography, characterized in that the simultaneously tested whole blood and platelet-poor plasma, determining the difference between the indices of R, K, Angle, MA, G and LY30 in samples from whole blood and depleted of plasma, respectively, and the value R, being in the normal range, a ΔR over 9 min diagnos tiruyut deficit humoral blood coagulation factors (II, V, VIII, IX, X, XII) or excessive activation of antithrombin III, with increasing index r and ΔR less than 9 min diagnosed failure platelet coagulation level, with increasing index ΔK over 4 min diagnose deficiency factors I and II or the presence of a high activity of natural anticoagulants, or medicines direct action, at higher than 32 ° ΔAngle also diagnose deficiency factors I and II, at normal rates MAi G, accompanied by an increase in performance and ΔMA ΔG above 26 mm and 6 kdyně / cm, respectively, diagnose deficiency of fibrinogen (factor I), or disturbance in its polymerization and hydration (dilution synthetic colloidal plasma substitutes deficit XIII clotting factor), with increasing index LY30bolee 8% simultaneously with an increase in LY30diagnostiruyut activation plasmin-dependent fibrinolysis, while increasing the index LY30bolee 8% under normal parameters LY30diagnostiruyut increased clot retraction (platelet hyperactivity) wherein: R- start time manner