PERIDINONES AS POLO-LIKE KINASE INHIBITORS

摘要

1. The compound having the structure in accordance with Formula (I): or its salts or solvates, where: X is C or N, and the dotted line means a single or double bond; A is a ring selected from the group consisting of phenyl, pyridine , pyrimidine, pyrazine, pyridazine, pyrrole, pyrazole, imidazole, thiazole, isothiazole, isoxazole, triazole, thiadiazole, benzimidazole, indole, pyrrolo [2,3-b] pyridine, quinoline, pyrrolidine, piperidine, piperazide and piperidine; methyl (e.g., -CD or -CH, more preferably -CH); R is hydrogen home, methyl (e.g. -CD or -CH), ethyl (e.g. -CDCD or -CHCH), -CH-cyclopropyl or -CHCF; R is methyl (e.g. -CD or -CH), ethyl (e.g. -CDCD or -CHCH) , -CH-cyclopropyl or -CHCF; or R and R, together with the carbon atom to which they are attached, optionally combine to form cyclobutyl; R is selected from the group consisting of -NH, -NHCH, -NH cyclopropyl, pyrrolidine, -CH-cyclopropyl , -CH (CH) -cyclopropyl, cyclopropyl, cyclobutyl optionally substituted with 1 or 2 fluorine atoms, cyclopentyl optionally substituted with 1 or 2 fluorine atoms, is ropil (e.g., —CH (CH) or —CD (CD)), —CHCHCF, tetrahydropyran, tetrahydrofuran, oxetane, phenyl optionally substituted with 1 or 2 substituents R, pyrazole optionally substituted with 1 substituent R, and pyrimidine; or R and R , together with the atoms to which they are attached, optionally combine to form a substituted or unsubstituted 5-7 membered heterocyclic ring selected from the group consisting of ,,,,,,, and, where denotes the central ring of Formula I, i.e. N is attached to R and C is attached to R; or R, R and R, together with the atoms to which they are attached