A PEPTIDE FOR IMPROVING THE BIO-STABILITY OF A BIOACTIVE SUBSTANCE AND A BIOACTIVE SUBSTANCE HAVING AN INCREASED BIO-STABILITY

摘要

1. A partial peptide of the GA module, comprising the amino acid sequence: Ile-Asp-Glu-Ile-Leu and containing 5-25 amino acids. The partial peptide of claim 1, wherein the GA module is isolated from streptococcus G148.3. The partial peptide according to claim 1, which contains 5-17 amino acids. The partial peptide according to claim 1, which consists of the amino acid sequence represented by the formula: Y-Y-Y-Y-Y-Y-Y-Y-Y-Y-Y-Y-Y-Y-Y-Y-Ile-Asp-Glu-Ile-Leu-Y-Y-Y-Y where Y is Lys or a deletion; Y represents Asn or a deletion; Y is a Leu or a deletion; Y is an Ile or deletion; Y represents Asn or a deletion; Y represents Asn or a deletion; Y is Ala or a deletion; Y is Lys or a deletion; Y is Thr or a deletion; Y represents Val or a deletion; Y is a Glu or deletion; Y is a Gly or a deletion; Y represents Val or a deletion; Y is Lys or a deletion; Y is Ala or a deletion; Y is a Leu or a deletion; Y is Ala or a deletion; Y is Ala or a deletion; Y is a Leu or a deletion; and Y is a Pro or deletion, provided that the deletion is limited to a continuous deletion from Y / Y (including a single deletion of Y or Y, and individual deletions in two regions of Y and Y) .5. The partial peptide according to claim 4, which is selected from the group consisting of: Ile-Asp-Glu-Ile-Leu (SEQ ID NO: 2); Ile-Asp-Glu-Ile-Leu-Ala-Ala (SEQ ID NO: 3); Leu-Ile-Asp-Glu-Ile-Leu-Ala-Ala (SEQ ID NO: 4); Lys-Ala-Leu-Ile-Asp-Glu-Ile-Leu-Ala-Ala (SEQ ID NO: 5); Val-Lys-Ala-Leu-Ile-Asp-Glu-Ile-Leu-Ala-Ala (SEQ ID NO: 6); Gly-Val-Lys-Ala-Leu-Ile-Asp-Glu-Ile- Leu-Ala (SEQ ID NO: 7); Gly-Val-Lys-Ala-Leu-Ile-Asp-Glu-Ile-Leu-Ala-Ala (SEQ ID NO: 8); Glu-Gly-Val-Lys- Ala-Leu-Ile-Asp-Glu-Ile-Leu-Ala-Ala (SEQ ID NO: 9); Val-Glu-Gly-Val-Lys-Ala-Leu-Ile-Asp-Glu-Ile-Leu-Ala -Ala (SEQ ID NO: 10); Thr-Val-Glu-Gly-Val-Lys-Ala-Leu-Ile-Asp-Glu-Ile-Leu (SEQ ID NO: 11); Ala-Lys-Thr-Val -Glu-Gly-Val-Lys-Ala-Leu-Ile-Asp-Glu-Ile-Leu (SEQ ID NO: