peptide for increased biostability of bioactive substance and biotive substance that has increased biostability.

摘要

Biostability enhancing peptide of bioactive substance and bioactive substance having increased biostability - The present invention aims to provide a peptide fragment capable of enhancing biostability of a bioactive substance while maintaining the activity of the bioactive substance, and a bioactive substance to which the peptide fragment is added. The present invention relates to a partial modulus ga of peptide having from 5 to 25 amino acids, which includes a partial modulus sequence ga (id of seq no: 1) and the amino acid sequence ile-asp-glu- ile-leu (seq id no: 2), and a bioactive complex in which the partial peptide of the ga module is bound to a bioactive substance. the bioactive substance includes glp-1, glp-2, gip, vip, somatostatin, amylin, ghrelin, derivatives thereof, and the like.