GETTING VERY SMALL AND uniformly sized paramagnetic or pseudo-paramagnetic nanoparticles based on iron oxide, and, with their use contrast agents T1-weighted MRI

摘要

1. A process for producing iron oxide nanoparticles, comprising: reacting an iron complex comprising iron as the central atom and a carboxylate group having from 4 to 25 carbon atoms ( "C4-C25"), linked to the central atom in the form of a ligand; C4-C25-fatty acid and a C4-C25-aliphatic alcohol or a C4-C25-aliphatic amine at a temperature of 150 to 350 ° C for zheleza.2 oxide nanoparticles. A method according to claim 1, further comprising dispersing the precipitate in an organic solvent, wherein the precipitate obtained by cooling and washing nanochastits.3 described above. The method of claim 1, wherein the size of the iron oxide nanoparticle is 4 nm or menee.4. The method of claim 1, wherein the iron complex has a fatty acid C10-C22-group bound to form liganda.5. A method according to claim 4, wherein the iron complex is zheleza.6 oleate. The method of claim 1, wherein the fatty acid and an aliphatic alcohol or aliphatic amine having from 10 to 22 carbon atoms ( "C10-C22"), sootvetstvenno.7. A method according to claim 6, wherein the fatty acid and the aliphatic alcohol are oleic acid and oleyl alcohol respectively, while the aliphatic amine is oleilaminom.8. The method of claim 1, wherein the preparation of the iron oxide nanoparticles is carried out raising the temperature from room temperature to a temperature of 200 to 310 ° C at a rate of temperature increase of 5 ° C / min or more, and conducting a reaction at a temperature of 200 to 310 ° C for a period of of from 5 to 60 minut.9. A method according to claim 8 wherein the rate of temperature rise of 10 ° C / min or bolee.10. The method of claim 1, wherein controlling the size of the iron oxide nanoparticles by adjusting the molar ratio of the fatty acid and an aliphatic alcohol or alifatiches