GETTING VERY SMALL AND uniformly sized paramagnetic or pseudo-paramagnetic nanoparticles based on iron oxide, and, with their use contrast agents T1-weighted MRI

摘要

1. The iron oxide nanoparticles with an average size of 4 nm or less, which are paramagnetic or pseudo-paramagnetic at a temperature of 20 K or above, having a uniform size, which is the average size of ± 1 nm.2. A contrast agent for T1-mode magnetic resonance imaging (MRI), comprising iron oxide nanoparticles according to claim. 1.3. The contrast agent of claim. 2, where the surface of the iron oxide nanoparticles modified with hydrophilic phospholipid-polyethylene glycol (phospholipid-PEG), polyethyleneglycol-phosphate (PO-PEG), phosphate, monosaccharide or derivatives thereof, citric acid or betainami.4. The contrast agent of claim. 2, where the surface of the iron oxide nanoparticles modified with glucose-6-phosphate, glucose 6-phosphate-ethanolamine or glucose 6-phosphate-polietilenglikolem.5. Iron oxide nanoparticles, characterized in that (a) are paramagnetic nanoparticles or pseudo-paramagnetic at 20 K or higher; (b) the size of each nanoparticle is in the range 1 to 4 nm; (c) the surface of the nanoparticle surrounded by a hydrophilic material; and (d) do not contain nanoparticle aggregates chastits.6. Iron oxide nanoparticles according to claim. 5, wherein the hydrophilic material is a phospholipid-polyethylene glycol, polyethylene glycol phosphate (PO-PEG), glucose-6-phosphate, glucose 6-phosphate-ethanolamine, glucose 6-phosphate-PEG, limonnoykislotoy or betaine .7. Colloidal solutions of iron oxide nanoparticles containing iron oxide nanoparticles according to claim. 5 dispersed in vode.8. Colloidal solutions of iron oxide nanoparticles containing iron oxide nanoparticles according to claim. 6 dispersed in vode.9. A contrast agent for T1-mode magnetic resonance imaging, comprising nanochas